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BIM-23190 aceate

BIM-23190 aceate 是一种生长抑素类似物，一种 SSTR2 和 SSTR5 的选择性激动剂。 BIM-23190 可用于癌症和肢端肥大症研究。

CAS号

分子式

C59H83N13O14S2

主要靶点

Somatostatin

仅限科研使用

Cat No : CM09668

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Synonyms

验证数据展示

  • CAS No.:

    BIM-23190 aceate
    CAS#:

产品信息

BIM-23190 aceate, a somatostatin analog, a selective agonist of SSTR2 and SSTR5. BIM-23190 can be used in cancer and acromegaly studies.

CAS号
分子式 C59H83N13O14S2
主要靶点 Somatostatin
主要通路 G蛋白偶联受体
分子量 1262.5
纯度 99.70%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

SST2:0.34 nM(Kd)|SST5:11.1 nM(Kd)

体内活性

In male athymic nude (nu/nu) mice, BIM-23190 (50 μg/mouse, twice a day) significantly reduced the tumor growth rate and exhibited significant anti-tumor (C6 glioma) activity[1].

体外活性

BIM-23190 tends to mildly stimulate PRL secretion. The Ki values are 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively[3].

溶解度

DMSO:12.63 mg/mL (10 mM)

参考文献

1.Federica Barbieri, et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1078-88.
2.T J Gillespie, et al. Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J Pharmacol Exp Ther. 1998 Apr;285(1):95-104.
3.I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92.

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