BML-278

MW = 391.5
C₂₄H₂₅NO₄
CAS Not found
MP = 141-143°C
>98% (TLC); NMR (Conforms)

A structurally novel activator of SIRT1 (EC₁₅₀= 1 M). Displays selectivity over SIRT2 and SIRT3 (EC₁₅₀= 25 M and 50 M respectively). Cell permeable.

Off white powder. May be dissolved in DMSO (5 mg/ml.

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

1. A Mai et al. J. Med. Chem. 2009, 52:5496