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BML-284

BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂，能够诱导 TCF 依赖的转录活性(EC50>700 nM)。

CAS号

853220-52-7

分子式

C19H18N4O3·HCl

主要靶点

Wnt/beta-catenin

仅限科研使用

Cat No : CM06890

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Synonyms

Wnt agonist 1

验证数据展示

  • CAS No.: 853220-52-7

    BML-284
    CAS#: 853220-52-7

产品信息

BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.

CAS号 853220-52-7
分子式 C19H18N4O3·HCl
主要靶点 Wnt/beta-catenin
主要通路 细胞骨架|干细胞
分子量 386.83
纯度 99.66%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Wnt agonist 1

靶点活性

TCF-dependent transcriptional activity:700 nM (EC50)

体内活性

In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification. [1]

体外活性

Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. [1]

溶解度

DMSO:77 mg/mL (199.05 mM),Ethanol:<1 mg/mL,H2O:<1 mg/mL

参考文献

1.Angew Chem Int Ed Engl. 2005, 44(13), 1987-1990.
2.Chen B, Zhao Y, Han D, et al. Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression[J]. Journal of Molecular and Cellular Cardiology. 2019.
3.Wang C, Peng R, Yuan X, et al. Cellular and molecular responses-mediated by DjMEK1/2 are necessary for planarian regeneration[J]. International Journal of Biological Macromolecules . 2020, 164: 3751-3761.

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