• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

BMS-202

BMS-202 (PD1-PDL1 inhibitor 2) 是一种非肽类 PD-1/PD-L 复合物抑制剂，其 IC50为 18 nM，KD 为 8 μM。它与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用，具有抗肿瘤活性。

CAS号

1675203-84-5

分子式

C25H29N3O3

主要靶点

PD-1/PD-L1|Apoptosis

仅限科研使用

Cat No : CM05770

Print datasheet

Synonyms

PD-1/PD-L1 inhibitor 2|PD1-PDL1 inhibitor 2

验证数据展示

  • CAS No.: 1675203-84-5

    BMS-202
    CAS#: 1675203-84-5

产品信息

PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2015034820 A1.

CAS号 1675203-84-5
分子式 C25H29N3O3
主要靶点 PD-1/PD-L1|Apoptosis
主要通路 凋亡|免疫与炎症|细胞周期
分子量 419.52
纯度 98.24%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 PD-1/PD-L1 inhibitor 2|PD1-PDL1 inhibitor 2

靶点活性

PD-1/PD-L1 interaction:0.018 μM

体外活性

BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1].

溶解度

DMSO:76 mg/mL(181.2 mM),Ethanol:83 mg/mL (197.85 mM)

参考文献

1.Louis S. Chupak, et al. Compounds useful as immunomodulators. WO 2015034820 A1
2.Yang X, Cheng B, Xiao Y, et al. Discovery of Novel CA-4 Analogs as Dual Inhibitors of Tubulin Polymerization and PD-1/PD-L1 Interaction for Cancer Treatment[J]. European Journal of Medicinal Chemistry. 2020: 113058.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2