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BMS-817399

BMS-817399 是一种具有口服活性的 CCR1 拮抗剂，具有结合亲和力和趋化性抑制效力的 IC50，可用于类风湿性关节炎的研究。

CAS号

1202400-18-7

分子式

C23H36ClN3O4

主要靶点

CCR

仅限科研使用

Cat No : CM11891

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Synonyms

BMS817399

验证数据展示

  • CAS No.: 1202400-18-7

    BMS-817399
    CAS#: 1202400-18-7

产品信息

BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis.

CAS号 1202400-18-7
分子式 C23H36ClN3O4
主要靶点 CCR
主要通路 免疫与炎症|微生物学
分子量 454
纯度 99.05%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 BMS817399

靶点活性

CCR1:1 nM (IC50)

溶解度

DMSO:55 mg/mL (121.14 mM)

参考文献

1.Chen H, et al. Moisture-Induced Amorphous Phase Separation of Amorphous Solid Dispersions: Molecular Mechanism, Microstructure, and Its Impact on Dissolution Performance. J Pharm Sci. 2018 Jan;107(1):317-326.
2.Khan JA, et al. Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR. J Mol Biol. 2015 Feb 27;427(4):924-42.
3.Santella JB 3rd, et al. Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem. 2014;57(18):7550-7564.

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The dilution calculator equation

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