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BPHA

BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。

CAS号

193807-60-2

分子式

C21H20N2O4S

主要靶点

MMP

仅限科研使用

Cat No : CM18266

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Synonyms

MMP-2/MMP-9 Inhibitor II

验证数据展示

  • CAS No.: 193807-60-2

    BPHA
    CAS#: 193807-60-2

产品信息

BPHA is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities.

CAS号 193807-60-2
分子式 C21H20N2O4S
主要靶点 MMP
主要通路 蛋白酶体
分子量 396.46
纯度 99.72%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 MMP-2/MMP-9 Inhibitor II

靶点活性

MMP-1:974 nM|MMP-2:12 nM|MMP-7:795 nM|MMP-9:16 nM|MMP-14:17 nM|MMP-3:>1000 nM

体内活性

Administration of BPHA (200 mg/kg; via oral; daily) in mice effectively suppresses tumor-induced angiogenesis, primary tumor growth, and liver metastasis. BPHA exhibits remarkable growth inhibitory activity of 48% and 45% in the B16-BL6 melanoma and F2 hemangio-endothelioma models, respectively.[1]

溶解度

DMSO:90.0 mg/mL (227.0 mM),Methanol:22.5 mg/mL (56.8 mM)

参考文献

1.Maekawa R, et al. Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor. Cancer Res. 1999;59(6):1231-1235.
2.Kohri T, et al. Reduction of experimental laser-induced choroidal neovascularization by orally administered BPHA, a selective metalloproteinase inhibitor. Graefes Arch Clin Exp Ophthalmol. 2003;241(11):943-952.
3.Maki H, et al. Antiangiogenic and antitumor effect of BPHA, an orally-active matrix metalloproteinase inhibitor, in in vivo murine and human tumor model. Gan To Kagaku Ryoho. 1999;26(11):1599-1606.

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