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BTS

BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂，可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。

CAS号

1576-37-0

分子式

C14H15NO2S

主要靶点

ATPase|Myosin

仅限科研使用

Cat No : CM00123

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Synonyms

N-Benzyl-p-toluenesulfonamide|N-苄基-对甲苯磺酸胺|N-Tosylbenzylamine

验证数据展示

  • CAS No.: 1576-37-0

    BTS
    CAS#: 1576-37-0

产品信息

BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) .

CAS号 1576-37-0
分子式 C14H15NO2S
主要靶点 ATPase|Myosin
主要通路 离子通道|细胞骨架
分子量 261.34
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 N-Benzyl-p-toluenesulfonamide|N-苄基-对甲苯磺酸胺|N-Tosylbenzylamine

靶点活性

Ca2+-stimulated myosin S1 ATPase:5 μM

体内活性

BTS is remarkably specific, as it was much less effective in suppressing contraction in rat myocardial or rabbit slow-twitch muscle, and did not inhibit platelet myosin II.?The isolation of BTS and the recently discovered Eg5 kinesin inhibitor, monastrol, suggests that motor proteins may be potential targets for therapeutic applications.

溶解度

DMSO:33.33 mg/mL (127.54 mM)

参考文献

1.Cheung A , Dantzig J A , Hollingworth S , et al. A small-molecule inhibitor of skeletal muscle myosin II[J]. Nature Cell Biology, 2001, 4(1):83-88.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2