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Batimastat

Batimastat (BB94) 是广谱MMP 抑制剂，能够抑制MMP-1 (IC50:3 nM)，MMP-2 (IC50:4 nM)，MMP-9 (IC50:4 nM)，MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。

CAS号

130370-60-4

分子式

C23H31N3O4S2

主要靶点

MMP

仅限科研使用

Cat No : CM05183

Print datasheet

Synonyms

BB94|巴马司他

验证数据展示

  • CAS No.: 130370-60-4

    Batimastat
    CAS#: 130370-60-4

产品信息

Batimastat (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.

CAS号 130370-60-4
分子式 C23H31N3O4S2
主要靶点 MMP
主要通路 蛋白酶体
分子量 477.64
纯度 98.21%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 BB94|巴马司他

靶点活性

MMP-3:20 nM|MMP-9:4 nM|MMP-1:3 nM|MMP-2:4 nM|MMP-7:6 nM

体内活性

Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. [1] In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).[3]Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures. [4]

体外活性

Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. [1]Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. [2]

溶解度

DMSO:47.8 mg/mL (100 mM)

参考文献

1.Chirivi RG, et al. Int J Cancer, 1994, 58(3), 460-464. 2.Botos I, et al. PNAS, 1996, 93(7), 2749-2754. 3.Wang X, et al. Cancer Res, 1994, 54(17), 4726-4728. 4.Taraboletti G, et al. J Natl Cancer Inst, 1995, 87(4), 293-298. 5.Liu Y, Wei H, Tang J, et al. Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation[J]. Chemosphere. 2020, 255: 126954.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2