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Bax inhibitor peptide V5 acetate

Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate（579492-81-2 free base)) 是一种 Bax 介导的细胞凋亡抑制剂，用于癌症治疗。

CAS号

T10463L

分子式

C29H54N6O8S

主要靶点

Apoptosis

仅限科研使用

Cat No : CM13647

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Synonyms

Bax inhibitor peptide V5 acetate（579492-81-2 free base)

验证数据展示

  • CAS No.: T10463L

    Bax inhibitor peptide V5 acetate
    CAS#: T10463L

产品信息

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

CAS号 T10463L
分子式 C29H54N6O8S
主要靶点 Apoptosis
主要通路 凋亡
分子量 646.85
纯度 99.20%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Bax inhibitor peptide V5 acetate（579492-81-2 free base)

体内活性

Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].

体外活性

Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) decreases cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells.[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2].

溶解度

DMSO:100 mg/mL (170.42 mM),H2O:100 mg/mL (170.42 mM),Sonification is recommended.

参考文献

1.Jo MJ, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65.
2.Rivas-Carrillo JD, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2