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Bcl-xL antagonist 2

Bcl-xL antagonist 2 是一种有效的选择性 Bcl-xL 拮抗剂，IC50 为 91 nM，Ki 为 65 nM。 Bcl-xL antagonist 2 可诱导癌细胞凋亡，可用于慢性淋巴细胞白血病和非霍奇金淋巴瘤的研究。

CAS号

1235032-75-3

分子式

C21H16N4O3S2

主要靶点

BCL

仅限科研使用

Cat No : CM19768

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Synonyms

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  • CAS No.: 1235032-75-3

    Bcl-xL antagonist 2
    CAS#: 1235032-75-3

产品信息

Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.

CAS号 1235032-75-3
分子式 C21H16N4O3S2
主要靶点 BCL
主要通路 凋亡
分子量 436.51
纯度 99.26%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

BCL-X L:0.091 μM

体内活性

Bcl-xL antagonist 2 (1 mg/kg;i.v.) exhibits good PK profile with CL, Vss, t1/2 and F of 0.47 mL/min/kg, 0.16 L/kg, 6.0 h and 16% in rats[1].

溶解度

DMSO:50 mg/mL (114.5 mM),Sonification is recommended.

参考文献

1.Koehler MF, et al. Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Med Chem Lett. 2014;5(6):662-667.
2.Wang L, et al. Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor. ACS Med Chem Lett. 2020;11(10):1829-1836.

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