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Benoxaprofen

Benoxaprofen (NSC-299582) 是长效的、强效的抗炎和解热化合物，在体外具有较弱的对环氧合酶的抑制作用，也可以抑制脂氧合酶，在一些炎症动物模型中抑制单核细胞迁移。

CAS号

51234-28-7

分子式

C16H12ClNO3

主要靶点

COX

仅限科研使用

Cat No : CM11957

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Synonyms

Benoxaphen. Compound 90459|NSC 299582|氧苯恶唑丙酸|LY-90459

验证数据展示

  • CAS No.: 51234-28-7

    Benoxaprofen
    CAS#: 51234-28-7

产品信息

Benoxaprofen is a non-steroidal anti-inflammatory drug.

CAS号 51234-28-7
分子式 C16H12ClNO3
主要靶点 COX
主要通路 神经科学|免疫与炎症
分子量 301.72
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Benoxaphen. Compound 90459|NSC 299582|氧苯恶唑丙酸|LY-90459

溶解度

DMSO:60 mg/ml (198.86 mM)

参考文献

1.Chin KY, El-Kayat B, Milne A, Hart A. Melanoma diagnosed 27 years after a benoxaprofen-induced photosensitivity reaction. J Dermatol Case Rep. 2012 Mar 27;6(1):5-7. doi: 10.3315/jdcr.2012.1087. PubMed PMID: 22514582; PubMed Central PMCID: PMC3322102.
2.Okada K, Kanoh H, Mohri K. Effects of clofibric acid on the biliary excretion of benoxaprofen glucuronide and taurine conjugate in rats. Pharmazie. 2011 Oct;66(10):777-83. PubMed PMID: 22026160.
3.Dong JQ, Smith PC. Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes. Drug Metab Dispos. 2009 Dec;37(12):2314-22. doi: 10.1124/dmd.109.028944. Epub 2009 Sep 22. PubMed PMID: 19773537; PubMed Central PMCID: PMC2784705.
4.Dong JQ, Liu J, Smith PC. Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo. Biochem Pharmacol. 2005 Sep 15;70(6):937-48. PubMed PMID: 16046212.

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