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验证数据展示

  • WB analysis of Y79 using 60326-1-Ig (same clone as 60326-1-PBS)

    WB analysis of Y79 using 60326-1-Ig (same clone as 60326-1-PBS)

    Y79 cells were subjected to SDS PAGE followed by western blot with 60326-1-Ig (Bestrophin-1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60326-1-PBS in a different storage buffer formulation.

  • WB analysis of Transfected HEK-293 using 60326-1-Ig (same clone as 60326-1-PBS)

    WB analysis of Transfected HEK-293 using 60326-1-Ig (same clone as 60326-1-PBS)

    WB result of Bestrophin-1 antibody (60326-1-Ig; 1:1000; room temperature for 1.5 hours) with negative control and Bestrophin-1 overexpressed Transfected HEK-293 cells. This data was developed using the same antibody clone with 60326-1-PBS in a different storage buffer formulation.

  • IF Staining of Y79 using 60326-1-Ig (same clone as 60326-1-PBS)

    IF Staining of Y79 using 60326-1-Ig (same clone as 60326-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Y79 cells using Bestrophin-1 antibody (60326-1-Ig, Clone: 4D5F1 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 60326-1-PBS in a different storage buffer formulation.

Bestrophin-1 Monoclonal antibody, PBS Only

Bestrophin-1 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 60326-1-PBS

产品说明书

CloneNo. 4D5F1

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

ARB, BEST, BEST1, bestrophin 1, Bestrophin-1, BMD, TU15B, VMD2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

60326-1-PBS targets Bestrophin-1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原 Bestrophin-1 fusion protein Ag15129 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 bestrophin 1
别名 ARB, BEST, BEST1, bestrophin 1, Bestrophin-1, BMD, TU15B, VMD2
计算分子量 585 aa, 68 kDa
观测分子量 68 kDa
GenBank蛋白编号BC015220
基因名称 Bestrophin/BEST1
Gene ID (NCBI) 7439
RRIDAB_2881436
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDO76090
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Bestrophin-1 (BEST1) is a 68 kDa transmembrane protein which belongs to the bestrophin family of anion channels. It is predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Studies show that bestrophin 1 functions as a Ca(2+)-dependent Cl(-) channel and modulator of voltage-dependent L-type Ca(2+) channels. It may also contribute to the basolateral cell conductance in airway epithelial cells. This protein is encoded by the VMD2 gene. Mutations in VMD2 can lead to different types of retinal or macular degenerations, including Best vitelliform macular dystrophy (BMD), autosomal recessive bestrophinopathy (ARB), autosomal dominant vitreoretinochoroidopathy (ADVIRC) and adult-onset vitelliform macular dystrophy (AVMD).