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Bimatoprost acid

Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物，对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比，它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。

CAS号

38344-08-0

分子式

C23H32O5

主要靶点

GPR

仅限科研使用

Cat No : CM10319

Print datasheet

Synonyms

17-phenyl trinor PGF2α|17-phenyl trinor Prostaglandin F2α

验证数据展示

  • CAS No.: 38344-08-0

    Bimatoprost acid
    CAS#: 38344-08-0

产品信息

Bimatoprost acid is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relative potency of 756% compared to PGF2α for binding to the FP receptor on ovine luteal cells.

CAS号 38344-08-0
分子式 C23H32O5
主要靶点 GPR
主要通路 内分泌与激素|G蛋白偶联受体
分子量 388.5
纯度 97.24%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 17-phenyl trinor PGF2α|17-phenyl trinor Prostaglandin F2α

溶解度

DMSO:65 mg/ml (167.31 mM)

参考文献

1.Yulia K , Kinuthia M W , Thoa T , et al. New Human Organotypic Corneal Tissue Model for Ophthalmic Drug Delivery Studies[J]. Investigative Ophthalmology & Visual Science, 2018, 59(7):2880-2898. 2.Klimko PG, Sharif NA. Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma. Br J Pharmacol. 2018 Apr 17. doi: 10.1111/bph.14327. [Epub ahead of print] Review. PubMed PMID: 29665040. 3.Shen J, Goodkin ML, Tong W, Attar M. Ocular pharmacokinetics and tolerability of bimatoprost ophthalmic solutions administered once or twice daily in rabbits, and clinical dosing implications. Clin Ophthalmol. 2017 Sep 28;11:1761-1767. doi: 10.2147/OPTH.S143428. eCollection 2017. Erratum in: Clin Ophthalmol. 2018 Aug 17;12:147PubMed PMID: 29026287; PubMed Central PMCID: PMC5627754. 4.Krupa M, Chodyński M, Ostaszewska A, Cmoch P, Dams I. A Novel Convergent Synthesis of the Potent Antiglaucoma Agent Tafluprost. Molecules. 2017 Jan 31;22(2). pii: E217. doi: 10.3390/molecules22020217. PubMed PMID: 28146132.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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