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Bisdemethoxycurcumin

Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。

CAS号

24939-16-0

分子式

C19H16O4

主要靶点

Epigenetic Reader Domain|Wnt/beta-catenin

仅限科研使用

Cat No : CM00912

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Synonyms

Curcumin III|双去甲氧基姜黄素|Didemethoxycurcumin

验证数据展示

  • CAS No.: 24939-16-0

    Bisdemethoxycurcumin
    CAS#: 24939-16-0

产品信息

Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].

CAS号 24939-16-0
分子式 C19H16O4
主要靶点 Epigenetic Reader Domain|Wnt/beta-catenin
主要通路 干细胞|表观遗传|细胞骨架
分子量 308.33
纯度 99.34%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Curcumin III|双去甲氧基姜黄素|Didemethoxycurcumin

溶解度

Ethanol:5 mg/mL,DMSO:10 mg/mL

参考文献

1.Fiala, M., Liu, P.T., Espinosa-Jeffrey, A., et al. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer’s disease patients are improved by bisdemethoxycurcumin. Proceedings of the National Academy of Sciences of the United States of America 104(31), 12849-12854 (2007). 2.Sandur, S.K., et al. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28(8), 1765-1773 (2007). 3.Ryu, M.J., et al. Natural derivatives of curcumin attenuate the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochemical and Biophysical Research Communications 377(4), 1304-1308 (2008).

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2