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Brevianamide F

Brevianamide F (Cyclo(L-Pro-L-Trp)) 是一种从Colletotrichum gloeosporioides 中分离得到的真菌毒素，属于天然存在的 2,5-二酮哌嗪类，具有抗菌活性。它具有PI3Kα抑制活性，IC50值为 4.8 µM。

CAS号

38136-70-8

分子式

C16H17N3O2

主要靶点

Antibacterial|BCRP|PI3K

仅限科研使用

Cat No : CM02622

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Synonyms

cyclo-(L-Trp-L-Pro)|Cyclo-L-tryptophyl-L-proline|Cyclo(L-Pro-L-Trp)

验证数据展示

  • CAS No.: 38136-70-8

    Brevianamide F
    CAS#: 38136-70-8

产品信息

Brevianamide F, also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess interesting breast cancer resistance protein inhibitory activity.

CAS号 38136-70-8
分子式 C16H17N3O2
主要靶点 Antibacterial|BCRP|PI3K
主要通路 微生物学|离子通道|PI3K/Akt/mTOR信号通路
分子量 283.32
纯度 97.30%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 cyclo-(L-Trp-L-Pro)|Cyclo-L-tryptophyl-L-proline|Cyclo(L-Pro-L-Trp)

靶点活性

PI3Kα:4.8 μM (IC50)

溶解度

DMSO:50 mg/mL (176.47 mM),Sonification is recommended.

参考文献

1.Borthwick AD. Chemical Reviews. 2012. 112 (7): 3641–3716.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2