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C-82

C-82 是一种特异性 CBP/β-catenin 拮抗剂。它抑制 β-catenin 和 CBP 之间的结合，并增加 β-catenin 和 p300 之间的结合。

CAS号

1422253-37-9

分子式

C33H34N6O4

主要靶点

Epigenetic Reader Domain|Wnt/beta-catenin

仅限科研使用

Cat No : CM06909

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Synonyms

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  • CAS No.: 1422253-37-9

    C-82
    CAS#: 1422253-37-9

产品信息

C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.

CAS号 1422253-37-9
分子式 C33H34N6O4
主要靶点 Epigenetic Reader Domain|Wnt/beta-catenin
主要通路 表观遗传|干细胞|细胞骨架
分子量 578.66
纯度 99.66%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile.

体外活性

C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs.

溶解度

DMSO:55 mg/ml (95.05 mM)

参考文献

1.Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2