验证数据展示
Planning an IHC experiment? We recommend our IHCeasy CA12 Ready-To-Use IHC Kit. CA12 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 15180-1-AP
产品信息
CL647-15180 targets CA12 in applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | Application Description |
| Tested Reactivity | human, mouse, rat |
| Immunogen | CA12 fusion protein Ag7107 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | carbonic anhydrase XII |
| Synonyms | CA12, Carbonate dehydratase XII, Carbonic anhydrase 12, carbonic anhydrase XII, CAXII, CA-XII, EC:4.2.1.1, HsT18816, Tumor antigen HOM RCC 3.1.3, Tumor antigen HOM-RCC-3.1.3, CA XII |
| Calculated Molecular Weight | 39 kDa |
| Observed Molecular Weight | 44 kDa, 75-80 kDa |
| GenBank Accession Number | BC000278 |
| Gene Symbol | CA12 |
| Gene ID (NCBI) | 771 |
| Conjugate | CoraLite® Plus 647 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 654 nm / 674 nm |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O43570 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CA12 belongs to the alpha-carbonic anhydrase family. It reversible hydration of carbon dioxide. Overexpression of the zinc enzyme CA12 is observed in certain human cancers. The structure reveals a prototypical CA fold; however, two CA12 domains associate to form an isologous dimer, an observation that is confirmed by studies of the enzyme in solution.