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Species Reactivity
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Conjugate
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验证数据展示

  • WB analysis using 26674-1-AP

    WB analysis using 26674-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 26674-1-AP (CACNA2D4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CACNA2D4 Polyclonal antibody

CACNA2D4 Polyclonal Antibody for WB, ELISA
Cat No. 26674-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

mouse, rat

应用

WB, ELISA

别名

Voltage-gated calcium channel subunit alpha-2/delta-4, Voltage-dependent calcium channel subunit delta-4, Voltage-dependent calcium channel subunit alpha-2-4, Voltage-dependent calcium channel subunit alpha-2/delta-4, RCD4

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inmouse brain tissue, rat brain tissue

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

26674-1-AP targets CACNA2D4 in WB, ELISA applications and shows reactivity with mouse, rat samples.

经测试应用 WB, ELISA Application Description
经测试反应性 mouse, rat
免疫原 CACNA2D4 fusion protein Ag24464 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 calcium channel, voltage-dependent, alpha 2/delta subunit 4
别名 Voltage-gated calcium channel subunit alpha-2/delta-4, Voltage-dependent calcium channel subunit delta-4, Voltage-dependent calcium channel subunit alpha-2-4, Voltage-dependent calcium channel subunit alpha-2/delta-4, RCD4
计算分子量 1137 aa, 128 kDa
观测分子量100 kDa
GenBank蛋白编号BC150186
基因名称 CACNA2D4
Gene ID (NCBI) 93589
RRIDAB_3669562
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ7Z3S7
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Calcium voltage-gated channel auxiliary subunit alpha2delta 4 (CACNA2D4, also known as RCD4) is a member of the alpha-2/delta subunit family within the voltage-dependent calcium channel complex. The α2δ4 subunit of retinal voltage-gated calcium channels (Cav), is crucial for developing and mature exocytotic function of the photoreceptor ribbon synapse (PMID: 29875267). CACNA2D4 is localized to the retina, particularly in photoreceptors, where it is essential for organizing synaptic ribbons and setting Cav1.4 voltage sensitivity (PMID: 28262416). In humans, mutations in CACNA2D4 are associated with autosomal recessive cone dystrophy, a condition that affects the photoreceptor cells in the retina (PMID: 16877424).

实验方案

Product Specific Protocols
WB protocol for CACNA2D4 antibody 26674-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols