验证数据展示
产品信息
28476-1-PBS targets CAPN3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | CAPN3 fusion protein Ag29454 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | calpain 3, (p94) |
Synonyms | Calpain-3, Calpain p94, Calpain L3, calpain 3, (p94), Calpain 3 |
Observed Molecular Weight | 90-105 kDa, 55-60 kDa, 30-35 kDa |
GenBank Accession Number | BC146672 |
Gene Symbol | CAPN3 |
Gene ID (NCBI) | 825 |
RRID | AB_2881150 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | P20807 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Calpain 3 (CAPN3), a major intracellular protease, is a muscle-specific member of the calpain large subunit family that specifically binds to titin. CAPN3 plays a role in the dysferlin protein complex and that disruption of CAPN3 function may affect muscle membrane repair and remodeling. CAPN3 has some isoforms with MW of 94, 84, 93, 36, 18 kDa. CAPN3 autolysis generates a small N-terminal fragment of 34 kDa and a large C-terminal fragment whose size ranges from 55 to 60 kDa during self-processing (PMID: 9794799, 14645524).