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CAY10602

CAY10602 是一种SIRT1激活剂，可剂量依赖性地抑制 THP-1 细胞中脂多糖对 TNF-α 的 NF-κB 依赖性诱导。

CAS号

374922-43-7

分子式

C22H15FN4O2S

主要靶点

Sirtuin

仅限科研使用

Cat No : CM06451

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Synonyms

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  • CAS No.: 374922-43-7

    CAY10602
    CAS#: 374922-43-7

产品信息

CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.

CAS号 374922-43-7
分子式 C22H15FN4O2S
主要靶点 Sirtuin
主要通路 DNA损伤和修复|表观遗传
分子量 418.44
纯度 98.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:41.8 mg/mL(100 mM)

参考文献

1.Höppner S, et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):35-50. 2.Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67.

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