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CCR6 antagonist 1

CCR6 antagonist 1 是一种 CCR6 拮抗剂，可抑制 CCL20/CCR6 信号通路。 CCR6 antagonist 1 可用于自身免疫介导的炎症性疾病的研究，如炎症性肠病 (IBDs)。

CAS号

588674-64-0

分子式

C17H12F3NO2

主要靶点

CCR

仅限科研使用

Cat No : CM09592

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Synonyms

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  • CAS No.: 588674-64-0

    CCR6 antagonist 1
    CAS#: 588674-64-0

产品信息

CCR6 antagonist 1 is a CCR6 antagonist. CCR6 antagonist 1 inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).

CAS号 588674-64-0
分子式 C17H12F3NO2
主要靶点 CCR
主要通路 免疫与炎症|微生物学
分子量 319.28
纯度 99.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

CCR6 antagonist 1 (1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice. CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects in Zymosan-induced peritonitis mice[1].

体外活性

CCR6 antagonist 1 (50 μM, 3 h) blocks the CCL20-induced CD4+ T cell migration. CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively[1].

溶解度

DMSO:90mg/mL (281.9mM)

参考文献

1.Maria Grazia Martina, et al. Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases. Eur J Med Chem. 2022 Aug 29;243:114703.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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