验证数据展示
产品信息
66611-1-PBS targets CCRL2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | Human |
Immunogen | CCRL2 fusion protein Ag4045 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | chemokine (C-C motif) receptor-like 2 |
Synonyms | C C chemokine receptor like 2, CCR11, CCR6, CCRL2, Chemokine receptor CCR11, Chemokine receptor X, CKRX, CRAM, CRAM A, CRAM B, HCR |
Calculated Molecular Weight | 344 aa, 40 kDa |
Observed Molecular Weight | 47 kDa |
GenBank Accession Number | BC025717 |
Gene Symbol | CCRL2 |
Gene ID (NCBI) | 9034 |
RRID | AB_2881971 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | O00421 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Chemokine CC motif receptor-like 2 (CCRL2) is a seven-transmembrane domain receptor that shares structural and functional similarities with the family of atypical chemokine receptors (ACKRs) (PMID: 28743719). CCRL2 does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. CCRL2 has been found on almost all hemopoietic cells, including monocytes, macrophages, polymorphonuclear neutrophils (PMNs), T cells, dendritic cells, natural killer cells, and CD34+ progenitor cells, with PMNs expressing the highest levels (PMID: 15188357). CCRL2 is also expressed by barrier cells, such as lymphatic and blood endothelial cells and bronchial and intestinal epithelial cells (PMID: 29056935).