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CCRL2 Monoclonal antibody, PBS Only

CCRL2 Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2C1E11

Cat no : 66611-1-PBS

Print datasheet

Synonyms

C C chemokine receptor like 2, CCR11, CCR6, CCRL2, Chemokine receptor CCR11, Chemokine receptor X, CKRX, CRAM, CRAM A, CRAM B, HCR

验证数据展示

  • WB analysis of HeLa using 66611-1-Ig (same clone as 66611-1-PBS)

    WB analysis of HeLa using 66611-1-Ig (same clone as 66611-1-PBS)

    HeLa cells and A431 cells were subjected to SDS PAGE followed by western blot with 66611-1-Ig (CCRL2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66611-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 66611-1-Ig (CCRL2 antibody) at dilution of 1:800 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66611-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    IHC staining of human spleen using 66611-1-Ig (same clone as 66611-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 66611-1-Ig (CCRL2 antibody) at dilution of 1:800 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66611-1-PBS in a different storage buffer formulation.

产品信息

66611-1-PBS targets CCRL2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen CCRL2 fusion protein Ag4045 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name chemokine (C-C motif) receptor-like 2
Synonyms C C chemokine receptor like 2, CCR11, CCR6, CCRL2, Chemokine receptor CCR11, Chemokine receptor X, CKRX, CRAM, CRAM A, CRAM B, HCR
Calculated Molecular Weight 344 aa, 40 kDa
Observed Molecular Weight 47 kDa
GenBank Accession NumberBC025717
Gene Symbol CCRL2
Gene ID (NCBI) 9034
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO00421
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Chemokine CC motif receptor-like 2 (CCRL2) is a seven-transmembrane domain receptor that shares structural and functional similarities with the family of atypical chemokine receptors (ACKRs) (PMID: 28743719). CCRL2 does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. CCRL2 has been found on almost all hemopoietic cells, including monocytes, macrophages, polymorphonuclear neutrophils (PMNs), T cells, dendritic cells, natural killer cells, and CD34+ progenitor cells, with PMNs expressing the highest levels (PMID: 15188357). CCRL2 is also expressed by barrier cells, such as lymphatic and blood endothelial cells and bronchial and intestinal epithelial cells (PMID: 29056935).