验证数据展示
产品信息
65566-1-PBS targets CD107b / LAMP2 in IF/ICC, FC (Intra) applications and shows reactivity with human samples.
经测试应用 | IF/ICC, FC (Intra) Application Description |
经测试反应性 | human |
免疫原 | Human adherent peripheral blood cells 种属同源性预测 |
宿主/亚型 | Mouse / IgG2a |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | lysosomal-associated membrane protein 2 |
别名 | CD107b, LAMP2, LAMP-2, LAMP 2, H4B4 |
计算分子量 | 45 kDa |
GenBank蛋白编号 | BC002965 |
基因名称 | LAMP2 |
Gene ID (NCBI) | 3920 |
ENSEMBL Gene ID | ENSG00000005893 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. Stable for one year after shipment. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
LAMP2 (CD107b) is a Lysosomal membrane glycoprotein. LAMP2 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP-2 is localized primarily in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, and in some tumor cells (PMID: 12221139). LAMP is involved in lysosomal stability and autophagy (PMID: 12221139). This glycoprotein provides selectins with carbohydrate ligands. LAMP2 may play a role in tumor cell metastasis (PMID 9426697).