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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of mouse bone marrow cells using 65055-1-Ig (same clone as 65055-1-PBS)

    FC experiment of mouse bone marrow cells using 65055-1-Ig (same clone as 65055-1-PBS)

    1X10^6 mouse bone marrow cells were surface stained with 0.2 ug Anti-Mouse CD11b (65055-1-Ig, Clone: M1/70) or 0.2 ug Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 65055-1-PBS in a different storage buffer formulation.

Anti-Mouse CD11b (M1/70), PBS Only

CD11b Monoclonal Antibody for FC
Cat No. 65055-1-PBS
CloneNo. M1/70

Host / Isotype

Rat / IgG2b, kappa

Reactivity

human, mouse

Applications

FC

Synonyms

M1/70, Ly 40, Itgam, integrin alpha M, CR3A

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -

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产品信息

65055-1-PBS targets CD11b in FC applications and shows reactivity with human, mouse samples.

Tested Applications FC Application Description
Tested Reactivity human, mouse
Immunogen C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes 种属同源性预测
Host / Isotype Rat / IgG2b, kappa
Class Monoclonal
Type Antibody
Full Name integrin alpha M
Synonyms M1/70, Ly 40, Itgam, integrin alpha M, CR3A
Calculated Molecular Weight127 kDa
GenBank Accession NumberBC156991
Gene Symbol CD11b
Gene ID (NCBI) 16409
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDE9Q604
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).