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Host
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Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
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Compatible Species
0
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验证数据展示

  • FC experiment of human PBMCs using 98057-1-RR (same clone as 98057-1-PBS)

    FC experiment of human PBMCs using 98057-1-RR (same clone as 98057-1-PBS)

    1x10^6 human PBMCs were stained with CoraLite® Plus 647 Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (CL647-65569, Clone: OKT3) and 0.25 ug Anti-Human CD126/IL-6R alpha Rabbit Recombinant Antibody (98057-1-RR, Clone: 240734A7), or Isotype Control. Cells were not fixed. This data was developed using the same antibody clone with 98057-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98057-1-RR (same clone as 98057-1-PBS)

    FC experiment of human PBMCs using 98057-1-RR (same clone as 98057-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD126/IL-6R alpha Rabbit Recombinant Antibody (98057-1-RR, Clone:240734A7) (red), or Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98057-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98057-1-RR

    Affinity and Kinetic Characterization of 98057-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98057-1-RR against Human CD126/IL-6R alpha were performed. The affinity constant is below 1 pM.

Anti-Human CD126/IL-6R alpha Rabbit Recombinant Antibody, PBS Only

CD126/IL-6R alpha Uni-rAbTM Recombinant Antibody for FC
Cat No. 98057-1-PBS

产品说明书

CloneNo. 240734A7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD126, IL-6R alpha, 240734A7, IL 6R alpha, IL 6R 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98057-1-PBS targets CD126/IL-6R alpha in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 6 receptor
别名 CD126, IL-6R alpha, 240734A7, IL 6R alpha, IL 6R 1
计算分子量 468 aa, 52 kDa
GenBank蛋白编号BC132684
基因名称 IL-6R alpha
Gene ID (NCBI) 3570
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP08887
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R alpha, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R alpha, the complex of IL-6 and IL-6R alpha associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL-6R alpha is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL-6R alpha has been found in human serum and urine (PMID: 2529343; 1545125).