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CD200 Recombinant antibody, PBS Only

CD200 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241346E6

Cat no : 84244-2-PBS

Print datasheet

Synonyms

OX 2, MRC, MOX2, MOX1, CD200 molecule

验证数据展示

  • WB analysis of human placenta using 84244-2-RR (same clone as 84244-2-PBS)

    WB analysis of human placenta using 84244-2-RR (same clone as 84244-2-PBS)

    human placenta tissue was subjected to SDS PAGE followed by western blot with 84244-2-RR (CD200 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84244-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84244-2-RR

    Affinity and Kinetic Characterization of 84244-2-RR

    Biolayer interferometry (BLl) kinetic assays of 84244-2-RR against Human CD200 were performed. The affinity constant is 4.34 nM.

产品信息

84244-2-PBS targets CD200 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Recombinant Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name CD200 molecule
Synonyms OX 2, MRC, MOX2, MOX1, CD200 molecule
Calculated Molecular Weight 269 aa, 30 kDa
Observed Molecular Weight45 kDa
GenBank Accession NumberBC022522
Gene Symbol CD200
Gene ID (NCBI) 4345
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP41217
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD200, also known as OX2, is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily (PMID: 3032785). It contains two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. CD200 is expressed on a variety of cell types, including thymocytes, B lymphocytes, a subset of T lymphocytes, follicular dendritic cells, neurons, and endothelial cells (PMID: 3032785; 10981966). CD200 binds to its receptor, CD200R, which is primarily expressed by myeloid and T cell lineage (PMID: 15187158). The CD200-CD200R interaction plays a role in immunosuppression and suppression of anti-tumor immune responses (PMID: 22020332).