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Anti-Human CD226 (11A8) Mouse IgG2a Recombinant Antibody, PBS Only

CD226 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

11A8

Cat no : 65573-1-PBS

Print datasheet

Synonyms

DNAM-1, DNAM1, DNAM 1, CD226 molecule, CD226 antigen

验证数据展示

  • FC experiment of human PBMCs using 65573-1-MR (same clone as 65573-1-PBS)

    FC experiment of human PBMCs using 65573-1-MR (same clone as 65573-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD226 Mouse Recombinant Antibody (65573-1-MR, Clone: 11A8) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). Cells were co-stained with CoraLite® Plus 405 Anti-Human CD3. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65573-1-PBS in a different storage buffer formulation.

产品信息

65573-1-PBS targets CD226 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Human NK Cells 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Recombinant
Type Antibody
Full Name CD226 molecule
Synonyms DNAM-1, DNAM1, DNAM 1, CD226 molecule, CD226 antigen
Calculated Molecular Weight 336 aa, 39 kDa
GenBank Accession NumberBC074787
Gene Symbol CD226
Gene ID (NCBI) 10666
ENSEMBL Gene IDENSG00000150637
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C. Stable for one year after shipment.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD226 (DNAM-1) is a ~65 kDa glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Interactions of CD226 and its ligands, CD155 and CD112, induce NK and T cell-mediated cytotoxicity and cytokine secretion (PMID: 15039383).