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Host
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Species Reactivity
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Species Reactivity
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验证数据展示

  • FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD244 Rabbit Recombinant Antibody (98133-1-RR, Clone: 241260G10) or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD3 (OKT3) Mouse IgG2a Recombinant Antibody (APC-65569, Clone: OKT3). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98133-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    FC experiment of human PBMCs using 98133-1-RR (same clone as 98133-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD244 Rabbit Recombinant Antibody (98133-1-RR, Clone:241260G10) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98133-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98133-1-RR

    Affinity and Kinetic Characterization of 98133-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98133-1-RR against Human CD244 were performed. The affinity constant is 1.29 nM.

Anti-Human CD244 Rabbit Recombinant Antibody, PBS Only

CD244 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98133-1-PBS

产品说明书

CloneNo. 241260G10

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

SLAMF4, NKR2B4, NK cell activation-inducing ligand, NAIL, h2B4

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98133-1-PBS targets CD244 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD244 molecule, natural killer cell receptor 2B4
别名 SLAMF4, NKR2B4, NK cell activation-inducing ligand, NAIL, h2B4
计算分子量 365 aa, 41 kDa
GenBank蛋白编号BC053985
基因名称 CD244
Gene ID (NCBI) 51744
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ9BZW8
储存缓冲液 PBS Only
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD244, also known as SLAMF4 or 2B4, is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family. It consists of an extracellular segment with two immunoglobulin (Ig)-like domains, a transmembrane region, and a cytoplasmic domain containing tyrosine-based motifs (PMID: 9841922; 30546369). CD244 is present on natural killer (NK) cells, γδ T cells, a subset of CD8+ T cells, monocytes, basophils, dendritic cells, and myeloid-derived suppressor cells (MDSCs) (PMID: 30546369). It binds to CD48 with high affinity and transmits stimulatory or inhibitory signals that regulate immune function (PMID: 9841922; 18523281).