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验证数据展示

  • IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 18308-1-AP (CD41/Integrin alpha 2b antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 18308-1-AP (CD41/Integrin alpha 2b antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

CD41/Integrin alpha 2b Polyclonal antibody, PBS Only

CD41/Integrin alpha 2b Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 18308-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

18308-1-PBS targets CD41/Integrin alpha 2b in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
别名
计算分子量 113 kDa
GenBank蛋白编号BC126442
基因名称 CD41a
Gene ID (NCBI) 3674
RRIDAB_2878529
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP08514
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light (25 kDa) and heavy (125 kDa) chains which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen.