• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

CD41/Integrin alpha 2b Polyclonal antibody, PBS Only

CD41/Integrin alpha 2b Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 18308-1-PBS

Print datasheet

Synonyms

验证数据展示

  • IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 18308-1-AP (CD41/Integrin alpha 2b antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 18308-1-AP (CD41/Integrin alpha 2b antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

产品信息

18308-1-PBS targets CD41/Integrin alpha 2b in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Synonyms
Calculated Molecular Weight 113 kDa
GenBank Accession NumberBC126442
Gene Symbol CD41a
Gene ID (NCBI) 3674
RRIDAB_2878529
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP08514
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light (25 kDa) and heavy (125 kDa) chains which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen.