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×
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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of human PBMCs using 98131-1-RR (same clone as 98131-1-PBS)

    FC experiment of human PBMCs using 98131-1-RR (same clone as 98131-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD47 Rabbit Recombinant Antibody (98131-1-RR, Clone: 240997D8) or 0.25 ug Isotype Control, and APC-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98131-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98131-1-RR (same clone as 98131-1-PBS)

    FC experiment of human PBMCs using 98131-1-RR (same clone as 98131-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD47 Rabbit Recombinant Antibody (98131-1-RR, Clone:240997D8) (red) or 0.25 ug Isotype Control (blue), and APC-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98131-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98131-1-RR

    Affinity and Kinetic Characterization of 98131-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98131-1-RR against Human CD47 were performed. The affinity constant is 0.723 nM.

Anti-Human CD47 Rabbit Recombinant Antibody, PBS Only

CD47 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98131-1-PBS

产品说明书

CloneNo. 240997D8

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

Leukocyte surface antigen CD47, Integrin-associated protein, Integrin associated protein, IAP, CD47 molecule

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98131-1-PBS targets CD47 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD47 molecule
别名 Leukocyte surface antigen CD47, Integrin-associated protein, Integrin associated protein, IAP, CD47 molecule
计算分子量 323 aa, 35 kDa
GenBank蛋白编号BC010016
基因名称 CD47
Gene ID (NCBI) 961
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ08722
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD47, also known as integrin-associated protein (IAP), is a member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. CD47 is heavily glycosylated and widely expressed by hematopoietic and nonhematopoietic cells. CD47 interacts with several membrane integrins and also acts as a receptor for thrombospondin (THBS1). It is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. CD47 also functions as a ligand for signal regulatory protein-α (SIRPα). Upon binding CD47, SIRPα initiates a signaling cascade that results in the inhibition of phagocytosis.