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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98170-1-RR (same clone as 98170-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98170-1-RR (same clone as 98170-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD48 Rabbit Recombinant Antibody (98170-1-RR, Clone:241389F8) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98170-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98170-1-RR (same clone as 98170-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98170-1-RR (same clone as 98170-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD48 Rabbit Recombinant Antibody (98170-1-RR, Clone:241389F8) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98170-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98170-1-RR

    Affinity and Kinetic Characterization of 98170-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98170-1-RR against Human CD48 were performed. The affinity constant is 0.383 nM.

Anti-Human CD48 Rabbit Recombinant Antibody, PBS Only

CD48 Recombinant Antibody for FC
Cat No. 98170-1-PBS

产品说明书

CloneNo. 241389F8

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD48 molecule, CD48 antigen, B-lymphocyte activation marker BLAST-1, BLAST1, BLAST

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98170-1-PBS targets CD48 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 CD48 molecule
别名 CD48 molecule, CD48 antigen, B-lymphocyte activation marker BLAST-1, BLAST1, BLAST
计算分子量 43 kDa
GenBank蛋白编号BC016182
基因名称 CD48
Gene ID (NCBI) 962
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP09326
储存缓冲液 PBS Only
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Signaling lymphocytic activation molecule family 2 (SLAMF2, CD48) is an adhesion and costimulatory molecule expressed constitutively on most hematopoietic cells, particularly in antigen-presenting cells (APC). CD48 is expressed on all the hematopoietic cells, both in humans and mice, except for murine neutrophils and long-term HSC. CD48 exists as both a membrane-bound (mCD48) and a soluble (sCD48) form. CD48 can activate T cells, antigen-presenting cells and granulocytes, by binding to CD2 or bacterial FimH, and through cell intrinsic effects. Interactions between CD48 and its high-affinity ligand CD244 are more complex, with both stimulatory and inhibitory outcomes. CD48 expression is increased in autoimmunity and allergy diseases, and anti-CD48 monoclonal antibodies have been shown to attenuate experimental autoimmune encephalomyelitis.