CD98/SLC3A2 Polyclonal antibody
CD98/SLC3A2 Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
mouse, rat
Applications
WB, ELISA
Conjugate
Unconjugated
验证数据展示
经过测试的应用
| Positive WB detected in | mouse kidney tissue, mouse pancreas tissue, mouse testis tissue, rat kidney tissue |
推荐稀释比
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:2000-1:12000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
31865-1-AP targets CD98/SLC3A2 in WB, ELISA applications and shows reactivity with mouse, rat samples.
| Tested Applications | WB, ELISA Application Description |
| Tested Reactivity | mouse, rat |
| Immunogen | Recombinant protein 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 |
| Synonyms | Slc3a2, Mdu1, CD98, Amino acid transporter heavy chain SLC3A2, 4F2hc |
| Calculated Molecular Weight | 58 kDa |
| Observed Molecular Weight | 75-80 kDa |
| GenBank Accession Number | NM_008577.4 |
| Gene Symbol | CD98/SLC3A2 |
| Gene ID (NCBI) | 17254 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | P10852-1 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CD98 is a cell-surface heterodimer consisting of a heavy chain (CD98hc) and a light chain. CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). This protein has 4 isoforms with the molecular mass of 58-71 kDa and can be detected 85-94 kDa due to glycosylation. The glycosylated CD98hc can links to a non-glycosylated light chain (~40 kDa) via a disulfide bond to form a heterodimeric CD98 antigen with molecular mass of 120-130 kDa (PMID: 14770309).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for CD98/SLC3A2 antibody 31865-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |