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CDC25B-IN-2

BIA 是一种 cdc25B 抑制剂。

CAS号

134271-74-2

分子式

C15H12N2O3

主要靶点

mTOR|Phosphatase

仅限科研使用

Cat No : CM20419

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Synonyms

验证数据展示

  • CAS No.: 134271-74-2

    CDC25B-IN-2
    CAS#: 134271-74-2

产品信息

BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.

CAS号 134271-74-2
分子式 C15H12N2O3
主要靶点 mTOR|Phosphatase
主要通路 代谢|PI3K/Akt/mTOR信号通路
分子量 268.27
纯度 99.12%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

The proliferation and cell viability of all cell lines were inhibited by treatment with 5?μM BIA.The IC50 values at 3 days were 1.7?±?0.1?μM for HT1080, 2.6?±?0.4?μM for MCF cells, 2.6?±?0.5?μM for MDA-MB-231 cells, and 2.4?±?0.4?μM for SKBR3 cells. Moreover, HT1080 cells stably overexpressing TMBIM6 showed high sensitivity to BIA[1].BIA decreases the binding between TMBIM6 and mTORC2, we performed a gel filtration assay in TMBIM6-overexpressing HT1080 cells after treatment with BIA during 24?h[1].

溶解度

DMSO:65 mg/ml (242.29 mM)

参考文献

1.Kim H K ,  Bhattarai K R ,  Junjappa R P , et al. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation[J]. Nature Communications, 2020, 11(1).

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