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Conjugate
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验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98169-1-RR

    FC experiment of human peripheral blood leukocytes using 98169-1-RR

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM3/6 (CD66c/d) Rabbit Recombinant Antibody (98169-1-RR, Clone: 241254D1) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • Affinity and Kinetic Characterization of 98169-1-RR

    Affinity and Kinetic Characterization of 98169-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98169-1-RR against Human CEACAM3/6 (CD66c/d) were performed. The affinity constant is 2.19 nM.

Anti-Human CEACAM3/6 (CD66c/d) Rabbit Recombinant Antibody

CEACAM3/6 (CD66c/d) Recombinant Antibody for FC
Cat No. 98169-1-RR

产品说明书

CloneNo. 241254D1

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD66c, CEACAM3/CD66d, CEACAM6, CEACAM6/CD66c, CEACAM3

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive FC detected inhuman peripheral blood leukocytes, FC receptor blocked human peripheral blood leukocytes

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98169-1-RR targets CEACAM3/6 (CD66c/d) in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 carcinoembryonic antigen-related cell adhesion molecule 3
别名 CD66c, CEACAM3/CD66d, CEACAM6, CEACAM6/CD66c, CEACAM3
计算分子量 252 aa, 27 kDa
GenBank蛋白编号BC106728
基因名称 CEACAM3
Gene ID (NCBI) 1084
RRIDAB_3672312
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP40198
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM3, also named as CD66d and CGM1, is exclusively expressed on granulocytes and acts as the major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms (PMID: 18606569). CEACAM6, also known as CD66c, is normally expressed on the surface of myeloid and epithelial surfaces and upregulated preferentially at the apical/luminal membranes of many tumors (PMID: 27595061; 35082925). This antibody is raised against 35-155 aa of human CEACAM3/CD66d and can cross-react with CEACAM6/CD66c.

实验方案

Product Specific Protocols
FC protocol for CEACAM3/6 (CD66c/d) antibody 98169-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols