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CHMFL-FLT3-122

CHMFL-FLT3-122 是一种强效口服 FLT3 激酶抑制剂，用于治疗 FLT3-ITD 阳性急性髓性白血病。CHMFL-FLT3-122能显著抑制 MV4-11细胞异种移植模型（50 mg/kg）的肿瘤生长，且在体内无明显毒性。

CAS号

1839150-56-9

分子式

C22H18ClF3N6O

主要靶点

FLT

仅限科研使用

Cat No : CM14249

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Synonyms

CHMFLFLT3122|CHMFL FLT3 122

验证数据展示

  • CAS No.: 1839150-56-9

    CHMFL-FLT3-122
    CAS#: 1839150-56-9

产品信息

CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (50 mg/kg) without exhibiting obvious toxicity in vivo.

CAS号 1839150-56-9
分子式 C22H18ClF3N6O
主要靶点 FLT
主要通路 蛋白酪氨酸激酶|血管生成
分子量 474.87
纯度 99.56%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 CHMFLFLT3122|CHMFL FLT3 122

溶解度

1eq. HCl:90.0 mg/mL (190.9 mM),DMSO:90.0 mg/mL (190.9 mM)

参考文献

1.Li X, et al. Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia. J Med Chem. 2015 Dec 24;58(24):9625-38.

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