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CLUH Recombinant antibody, PBS Only

CLUH Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241640C11

Cat no : 84321-4-PBS

Print datasheet

Synonyms

KIAA0664, Protein KIAA0664, FLJ23672, CLU1, 241640C11

验证数据展示

  • IF Staining of HeLa using 84321-4-RR (same clone as 84321-4-PBS)

    IF Staining of HeLa using 84321-4-RR (same clone as 84321-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CLUH antibody (84321-4-RR, Clone: 241640C11 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84321-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84321-4-RR

    Affinity and Kinetic Characterization of 84321-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84321-4-RR against Human CLUH were performed. The affinity constant is 7.19 nM.

产品信息

84321-4-PBS targets CLUH in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen CLUH fusion protein Ag34275 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name KIAA0664
Synonyms KIAA0664, Protein KIAA0664, FLJ23672, CLU1, 241640C11
GenBank Accession NumberBC156940
Gene Symbol CLUH
Gene ID (NCBI) 23277
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDO75153
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Clustered mitochondria homolog (CLUH) is a conserved RNA-binding protein, that binds transcripts encoding proteins involved in the respiratory chain, the tricarboxylic acid (TCA) cycle, and other mitochondrial metabolic pathways. Upon loss of CLUH, target mRNAs are subjected to faster decay, and their respective proteins are decreased in abundance. This leads to alterations in mitochondrial distribution (mitochondrial clustering as the gene name alludes to) mitochondrial cristae integrity, respiratory defects, loss of mtDNA, and decreased activity of TCA cycle enzymes. (PMID: 35559794)