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CNGA2 Polyclonal antibody

CNGA2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 23823-1-AP

Print datasheet

Synonyms

Cyclic nucleotide-gated channel alpha-2, CNG-2, CNG channel alpha-2, CNCG2, CNCA1

验证数据展示

  • WB analysis using 23823-1-AP

    WB analysis using 23823-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 23823-1-AP (CNGA2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inA431 cells, HepG2 cells, mouse brain tissue, rat brain tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

23823-1-AP targets CNGA2 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen CNGA2 fusion protein Ag19899 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name cyclic nucleotide gated channel alpha 2
Synonyms Cyclic nucleotide-gated channel alpha-2, CNG-2, CNG channel alpha-2, CNCG2, CNCA1
Calculated Molecular Weight 664 aa, 76 kDa
Observed Molecular Weight80 kDa
GenBank Accession NumberBC126302
Gene Symbol CNGA2
Gene ID (NCBI) 1260
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen Affinity purified
UNIPROT IDQ16280
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Cyclic nucleotide-gated (CNG) channels are crucial for visual and olfactory transductions (PMID: 12432397). Native CNG channels are heterotetramers composed of homologous A and B subunits. The olfactory CNG channels are composed of two CNGA2 subunits, one CNGA4 and one CNGB1b subunit, each containing a cyclic nucleotide-binding domain (PMID: 22786723). CNGA2, also named as CNCA, CNCA1 and CNCG2, is the primary subunit of the olfactory CNG channel. Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. Activation of olfactory channel by cyclic nucleotides leads to a depolarization of olfactory sensory neurons.

实验方案

Product Specific Protocols
WB protocol for CNGA2 antibody 23823-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols