验证数据展示
发表文章中的应用
| WB | See 2 publications below |
产品信息
18305-1-AP targets Collagen Type IV in WB, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | mouse, rat |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | collagen, type IV, alpha 3 (Goodpasture antigen) |
| 别名 | COL4A3, Collagen alpha 3(IV) chain, Collagen Type IV, Goodpasture antigen |
| 计算分子量 | 162 kDa |
| GenBank蛋白编号 | NM_000091 |
| 基因名称 | COL4A3 |
| Gene ID (NCBI) | 1285 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q01955 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Tumstatin is a cleavage fragment(C-term-245aa) corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. Tumstatin indicated proapoptotic activity by selective inhibition of protein synthesis on endothelial cells. At normal physiologic levels, tumstatin, a cleavage product of the alpha3 chain of type IV collagen, is capable of suppressing pathologic angiogenesis and tumor growth, according to animal study findings published in the June issue of Cancer Cell.
发表文章
| Species | Application | Title |
|---|---|---|
Food Funct Quercetin prevents the USP22-Snail1 signaling pathway to ameliorate diabetic tubulointerstitial fibrosis | ||
World J Diabetes Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study |