验证数据展示
产品信息
83010-3-PBS targets COL6A3-Specific as part of a matched antibody pair:
MP00027-1: 83010-3-PBS capture and 83010-4-PBS detection (validated in Cytometric bead array)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| Tested Applications | FC (Intra), Cytometric bead array, Indirect ELISA Application Description |
| Tested Reactivity | human |
| Immunogen | COL6A3-Specific fusion protein Ag34752 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | collagen, type VI, alpha 3 |
| Synonyms | COL6A3, Collagen Type VI, Collagen alpha-3(VI) chain, Collagen alpha 3(VI) chain, 230540D3 |
| Calculated Molecular Weight | 344 kDa |
| Observed Molecular Weight | 343 kDa |
| GenBank Accession Number | NM_004369 |
| Gene Symbol | COL6A3 |
| Gene ID (NCBI) | 1293 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P12111 |
| Storage Buffer | 100% PBS pH 7.3 |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
COL6A3 belongs to the type VI collagen family. Collagen VI acts as a cell-binding protein. It is expected to be expressed in smooth muscle. And the calculated molecular weight of COL6A3 is 343 kDa. The protein has similar expression in obese and T2DM (2 patients, and it regulates the chemotaxis and inflammation of macrophages in adipose tissue. Its expression is also related to weight gain. The expression of this protein in adipocytes is related to insulin resistance, which is believed to depend on PPAR (peroxisome proliferator-activated receptor) α-mediated adipocyte development (PMID: 25337653). Defects in COL6A3 are a cause of Bethlem myopathy (BM). Defects in COL6A3 are a cause of Ullrich congenital muscular dystrophy (UCMD) which also known as Ullrich scleroatonic muscular dystrophy. This antibody is specific to COL6A3.