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  • Featured Product
  • KD/KO Validated

COSMC Polyclonal antibody, PBS Only

COSMC Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 19254-1-PBS

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Synonyms

验证数据展示

  • WB analysis of HeLa using 19254-1-AP (same clone as 19254-1-PBS)

    WB analysis of HeLa using 19254-1-AP (same clone as 19254-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 19254-1-AP (COSMC antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19254-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19254-1-AP (COSMC antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19254-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    IHC staining of human colon cancer using 19254-1-AP (same clone as 19254-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19254-1-AP (COSMC antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19254-1-PBS in a different storage buffer formulation.

产品信息

19254-1-PBS targets COSMC in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen COSMC fusion protein Ag6899 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name C1GALT1-specific chaperone 1
Synonyms
Calculated Molecular Weight 36 kDa
Observed Molecular Weight 36-37 kDa
GenBank Accession NumberBC050441
Gene Symbol COSMC
Gene ID (NCBI) 29071
RRIDAB_10638003
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ96EU7
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

COSMC (C1GALT1C1) is a molecular chaperone required for expression of active T-synthase (CIGALT1) which catalyzes the synthesis of Tn antigen. Tn antigens are cancer-associated glycans and play an important role in tumor progression. Dysfunctional COSMC is able to convert a wild type protein into a tumor-specific antigen affecting tumor cell biology. COSMC overexpression had been observed in various cancers. COSMC mutations have been observed in an autoimmune disease Tn syndrome.