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CPI203

CAS号

202591-23-9

分子式

C19H18ClN5OS

主要靶点

Epigenetic Reader Domain

仅限科研使用

Cat No : CM19253

Print datasheet

Synonyms

EpigeneticReaderDomain|Epigenetic Reader Domain|CPI-203|CPI203|CPI 203|BRD4

验证数据展示

  • CAS No.: 202591-23-9

    CPI203
    CAS#: 202591-23-9

产品信息

CAS号 202591-23-9
分子式 C19H18ClN5OS
主要靶点 Epigenetic Reader Domain
主要通路 表观遗传
分子量 399.9
纯度 99.71%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 EpigeneticReaderDomain|Epigenetic Reader Domain|CPI-203|CPI203|CPI 203|BRD4

靶点活性

BET BD:37 nM

体外活性

CPI203 在体外及细胞内抑制BRD4，而不影响其体外的激酶活性。[1] CPI203 在分析的所有9个MCL细胞系中显示出细胞静止效果，GI50范围从0.06到0.71 μM，对健康捐献者的正常PBMCs具有低细胞性毒性。此外，lenalidomide和CPI203通过靶向IRF4和MYC，有效激活对bortezomib有抵抗性的MCL细胞中的细胞死亡程序。[2]

溶解度

DMSO:200 mM

细胞实验

MCL primary cells and cell lines are incubated as indicated with lenalidomide and/or CPI203. MTT is added for 2-6 additional hours before spectrophotometric measurement. Each measurement is made in triplicate. Values are represented using untreated control cells. The GI50 is calculated as the concentration that produced 50 % growth inhibition. Combination indexes (CIs) are calculated by using the Calcusyn software version 2.0. The interaction between two drugs is considered synergistic when CI <1. (Only for Reference)

参考文献

1.Devaiah BN, et al. Proc Natl Acad Sci U S A. 2012, 109(18), 6927-6932.
2.Moros A, et al. Leukemia. 2014. doi: 10.1038/leu.2014.106.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2