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CPN2 Polyclonal antibody, PBS Only

CPN2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 27160-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 27160-1-AP (same clone as 27160-1-PBS)

    WB analysis using 27160-1-AP (same clone as 27160-1-PBS)

    human plasma tissue were subjected to SDS PAGE followed by western blot with 27160-1-AP (CPN2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27160-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 27160-1-AP (same clone as 27160-1-PBS)

    IHC staining of human liver using 27160-1-AP (same clone as 27160-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27160-1-AP (CPN2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27160-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 27160-1-AP (same clone as 27160-1-PBS)

    IHC staining of human liver using 27160-1-AP (same clone as 27160-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27160-1-AP (CPN2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27160-1-PBS in a different storage buffer formulation.

产品信息

27160-1-PBS targets CPN2 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen CPN2 fusion protein Ag25801 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name carboxypeptidase N, polypeptide 2
Synonyms
Calculated Molecular Weight 545 aa, 61 kDa
Observed Molecular Weight83-90 kDa
GenBank Accession NumberBC031569
Gene Symbol CPN2
Gene ID (NCBI) 1370
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP22792
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Human carboxypeptidase N (CPN), a member of the CPN/E subfamily of "regulatory" metallo-carboxypeptidases, is an extracellular glycoprotein synthesized in the liver and secreted into the blood, where it controls the activity of vasoactive peptide hormones, growth factors and cytokines by specifically removing C-terminal basic residues. Normally, CPN circulates in blood plasma as a hetero-tetramer consisting of two 83 kDa (CPN2) domains each flanked by a 48 to 55 kDa catalytic (CPN1) domain (PMID:17157876). CPN2 also performs a crucial biological function in the invasion and migration of breast cancer and can be used as a biomarker for effective diagnosis and treatment of breast cancer.