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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Conjugate
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Compatible Species
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Conjugate
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验证数据展示

  • WB analysis using 66763-1-Ig (same clone as 66763-1-PBS)

    WB analysis using 66763-1-Ig (same clone as 66763-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66763-1-Ig (CRM1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Lamin B1 Monoclonal antibody (HRP-66095) as loading control. This data was developed using the same antibody clone with 66763-1-PBS in a different storage buffer formulation.

  • IHC staining of human cervical cancer using 66763-1-Ig (same clone as 66763-1-PBS)

    IHC staining of human cervical cancer using 66763-1-Ig (same clone as 66763-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 66763-1-Ig (CRM1 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66763-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CRM1 antibody included
  • IHC staining of human cervical cancer using 66763-1-Ig (same clone as 66763-1-PBS)

    IHC staining of human cervical cancer using 66763-1-Ig (same clone as 66763-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 66763-1-Ig (CRM1 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66763-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CRM1 antibody included
  • IF Staining of HeLa using 66763-1-Ig (same clone as 66763-1-PBS)

    IF Staining of HeLa using 66763-1-Ig (same clone as 66763-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CRM1 antibody (66763-1-Ig, Clone: 2D3B6 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 66763-1-PBS in a different storage buffer formulation.

CRM1 Monoclonal antibody, PBS Only

CRM1 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 66763-1-PBS

产品说明书

CloneNo. 2D3B6

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

XPO1, Exportin-1, Exportin 1, Exp1, 2D3B6

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy CRM1 Ready-To-Use IHC Kit. CRM1 primary antibody included.

产品信息

66763-1-PBS targets CRM1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 CRM1 fusion protein Ag27337 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 exportin 1 (CRM1 homolog, yeast)
别名 XPO1, Exportin-1, Exportin 1, Exp1, 2D3B6
计算分子量 1071 aa, 123 kDa
观测分子量 100-110 kDa
GenBank蛋白编号BC032847
基因名称 CRM1
Gene ID (NCBI) 7514
RRIDAB_2882109
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO14980
储存缓冲液 PBS Only
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).