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Species Reactivity
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验证数据展示

  • IHC staining of mouse kidney using 66915-1-Ig (same clone as 66915-1-PBS)

    IHC staining of mouse kidney using 66915-1-Ig (same clone as 66915-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 66915-1-Ig (CX3CR1 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66915-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse kidney using 66915-1-Ig (same clone as 66915-1-PBS)

    IF Staining of mouse kidney using 66915-1-Ig (same clone as 66915-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using CX3CR1 antibody (66915-1-Ig, Clone: 3D3B8 ) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66915-1-PBS in a different storage buffer formulation.

  • WB analysis using 66915-1-Ig (same clone as 66915-1-PBS)

    WB analysis using 66915-1-Ig (same clone as 66915-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66915-1-Ig (CX3CR1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66915-1-PBS in a different storage buffer formulation.

CX3CR1 Monoclonal antibody, PBS Only

CX3CR1 Monoclonal Antibody for WB, IHC, IF-P, ELISA
Cat No. 66915-1-PBS

产品说明书

CloneNo. 3D3B8

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

WB, IHC, IF-P, ELISA

别名

CMK BRL1, CMK BRL 1, CCRL1, C X3 C CKR 1, Beta chemokine receptor-like 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

66915-1-PBS targets CX3CR1 in WB, IHC, IF-P, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF-P, ELISA Application Description
经测试反应性 human, mouse
免疫原 CX3CR1 fusion protein Ag27698 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 chemokine (C-X3-C motif) receptor 1
别名 CMK BRL1, CMK BRL 1, CCRL1, C X3 C CKR 1, Beta chemokine receptor-like 1
计算分子量 40 kDa
观测分子量 44 kDa
GenBank蛋白编号BC028078
基因名称 CX3CR1
Gene ID (NCBI) 1524
RRIDAB_2882242
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP49238
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CX3CR1, also known as GPR13, V28, and fractalkine receptor, belongs to the 7-transmembrane G protein-coupled receptor (GPCR) family. It is expressed in microglia, astrocytes, NK cells, monocytes/macrophages, and a subpopulation of T cells. CX3CR1 is the receptor for fractalkine (CX3CL1) and mediates both its adhesive and migratory functions. It also acts as a coreceptor with CD4 for HIV-1 virus envelope protein (in vitro), and some variations in the gene of CX3CR1 lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Defects in CX3CR1 are a cause of susceptibility to age-related macular degeneration type 12 (ARMD12).