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  • Featured Product
  • KD/KO Validated

Calsequestrin 2 Polyclonal antibody, PBS Only

Calsequestrin 2 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat, pig

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 18422-1-PBS

Print datasheet

Synonyms

验证数据展示

  • WB analysis using 18422-1-AP (same clone as 18422-1-PBS)

    WB analysis using 18422-1-AP (same clone as 18422-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

  • IHC staining of human heart using 18422-1-AP (same clone as 18422-1-PBS)

    IHC staining of human heart using 18422-1-AP (same clone as 18422-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 18422-1-AP (Calsequestrin 2 antibody at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

  • IHC staining of human heart using 18422-1-AP (same clone as 18422-1-PBS)

    IHC staining of human heart using 18422-1-AP (same clone as 18422-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 18422-1-AP (Calsequestrin 2 antibody at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

  • IF Staining of C2C12 using 18422-1-AP (same clone as 18422-1-PBS)

    IF Staining of C2C12 using 18422-1-AP (same clone as 18422-1-PBS)

    Immunofluorescent analysis of (-20℃ Ethanol) fixed C2C12 cell using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

产品信息

18422-1-PBS targets Calsequestrin 2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

Tested Applications WB, IHC, IF/ICC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat, pig
Immunogen Calsequestrin 2 fusion protein Ag13246 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name calsequestrin 2 (cardiac muscle)
Synonyms
Calculated Molecular Weight 46 kDa
Observed Molecular Weight 50 kDa
GenBank Accession NumberBC022288
Gene Symbol Calsequestrin 2
Gene ID (NCBI) 845
RRIDAB_2071473
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO14958
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.