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Cambinol

Cambinol (SIRT1/2 Inhibitor IV) 是一种SIRT1和SIRT2的抑制剂，IC50值分别为 56 μM 和 59 μM。它是中性鞘磷脂酶的外泌体抑制剂。

CAS号

14513-15-6

分子式

C21H16N2O2S

主要靶点

Sirtuin|Apoptosis|Phospholipase

仅限科研使用

Cat No : CM11341

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Synonyms

SIRT1/2 Inhibitor IV|NSC 112546

验证数据展示

  • CAS No.: 14513-15-6

    Cambinol
    CAS#: 14513-15-6

产品信息

Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)

CAS号 14513-15-6
分子式 C21H16N2O2S
主要靶点 Sirtuin|Apoptosis|Phospholipase
主要通路 DNA损伤和修复|代谢|表观遗传|凋亡
分子量 360.43
纯度 98.47%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 SIRT1/2 Inhibitor IV|NSC 112546

靶点活性

SIRT2:59 μM|SIRT1:56μM

溶解度

DMSO:10 mg/mL,Ethanol:5 mg/mL

参考文献

1.Lugrin J.,et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510.
2.Figuera-Losada M., et al. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One. 2015 May 26;10(5):e20124481.

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