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Carbidine

Carbidine (Carbidin) 是γ-carboline 的衍生物，一种非典型的抗精神病药物。它可以在体内和体外降低DA 对伏隔核突触体释放3H-DA 和酪氨酸羟化酶活性的抑制作用。

CAS号

33162-17-3

分子式

C13H20Cl2N2

主要靶点

Others

仅限科研使用

Cat No : CM08178

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Synonyms

Carbidin|Karbidine|Karbidin|Carbidine dihydrochloride

验证数据展示

  • CAS No.: 33162-17-3

    Carbidine
    CAS#: 33162-17-3

产品信息

Carbidine is a derivative of gamma-carboline, an atypical antipsychotic drug. It reduces the inhibitory effect of DA on the 3H-DA release from synaptosomes of the nucleus accumbens septi and on the activity of tyrosine hydroxylase in vivo and in vitro.

CAS号 33162-17-3
分子式 C13H20Cl2N2
主要靶点 Others
主要通路 其他
分子量 275.217
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Carbidin|Karbidine|Karbidin|Carbidine dihydrochloride

体内活性

After the administration of Carbidine(5 mg/kg, i.p.), the maximal IFC of Carbidine was found to be approximately 1 mu M 20-40 min after injection. Carbidine(1 mu M, i.p.) produces elevation of dopamine release not affecting sufficiently its metabolite dialysate levels. Carbidine(0.2 and 0.5 mg/kg, i.p.) stimulated locomotor activity of non-operated rats[1].

溶解度

DMSO:2.75 mg/mL (10 mM),Need ultrasound

参考文献

1.Proskuriakova TV, Gurtovenko VM, Gorshkova EP. [Comparative evaluation of the effect of carbidine and levamisole on the E-rosette-forming activity of the lymphocytes in alcoholic intoxication]. Farmakol Toksikol. 1989 Jan-Feb;52(1):94-8. Russian.
2.Kudrin VS, et al. [Effect of the atypical neuroleptics carbidine and sulpiride on dopamine biosynthesis in the synaptosomes of the nucleus accumbens septi in rats]. Farmakol Toksikol. 1987 Mar-Apr;50(2):16-20. Russian.
3.Zharkovskiĭ AM, Klassen NE, Zharkovskiĭ TA. [Effect of carbidine on the dopamine and serotonin receptors of the central nervous system]. Biull Eksp Biol Med. 1985 Jun;99(6):700-2. Russian.
4.Gainetdinov RR, et al. Simultaneous monitoring of dopamine, its metabolites and trans-isomer of atypical neuroleptic drug carbidine concentrations in striatal dialysates of conscious rats. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Feb;20(2):291-305.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2