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Carbidopa

Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。

CAS号

28860-95-9

分子式

C10H14N2O4

主要靶点

Decarboxylase|Aryl Hydrocarbon Receptor

仅限科研使用

Cat No : CM03633

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Synonyms

(S)-(-)-Carbidopa|Lodosyn|卡比多巴

验证数据展示

  • CAS No.: 28860-95-9

    Carbidopa
    CAS#: 28860-95-9

产品信息

Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.

CAS号 28860-95-9
分子式 C10H14N2O4
主要靶点 Decarboxylase|Aryl Hydrocarbon Receptor
主要通路 其他|免疫与炎症|代谢
分子量 226.23
纯度 98.68%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (S)-(-)-Carbidopa|Lodosyn|卡比多巴

靶点活性

aromatic-L-amino-acid decarboxylase:29 μM

溶解度

DMSO:4.5 mg/mL (20 mM)

参考文献

1.Durso, R., et al., Variable absorption of carbidopa affects both peripheral and central levodopa metabolism. J Clin Pharmacol, 2000. 40(8): p. 854-60.
2.Orlefors, H., et al., Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography. Eur J Nucl Med Mol Imaging, 2006. 33(1): p. 60-5.

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