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Carbimazole

Carbimazole (Athyromazole) 是咪唑类甲状腺拮抗试剂，在体内快速转化为 MMI 而发挥作用，在体外可转化为甲咪唑，可用于 Graves 病的研究。

CAS号

22232-54-8

分子式

C7H10N2O2S

主要靶点

Thyroid hormone receptor(THR)

仅限科研使用

Cat No : CM00138

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Synonyms

Carbimazol|卡比吗唑|Neomercazole|卡比马唑|Athyromazole

验证数据展示

  • CAS No.: 22232-54-8

    Carbimazole
    CAS#: 22232-54-8

产品信息

Carbimazole is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.

CAS号 22232-54-8
分子式 C7H10N2O2S
主要靶点 Thyroid hormone receptor(THR)
主要通路 内分泌与激素
分子量 186.23
纯度 99.22%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Carbimazol|卡比吗唑|Neomercazole|卡比马唑|Athyromazole

体内活性

Carbimazole被人体吸收后转化为甲巯咪唑,产生抗甲状腺作用,作用于抗甲亢(过度产生甲状腺激素)和甲状腺毒症(甲状腺炎症)。

溶解度

Ethanol:12 mg/mL (64.4 mM),H2O:<1 mg/mL,DMSO:36 mg/mL (193.3 mM)

参考文献

1.Taurog A, et al. Endocrinology, 1976, 98(4), 1031-1046.
2.Magnusson RP, et al. J Biol Chem, 1984, 259(1), 197-205.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2