• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Cardiogenol C hydrochloride

Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂，能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内，它可以对已经沿袭的祖细胞类型产生心肌生成效应，是一种心肌生成试剂，在动物模型中可以用作细胞移植研究中提高心脏修复的工具。

CAS号

1049741-55-0

分子式

C13H17ClN4O2

主要靶点

Wnt/beta-catenin

仅限科研使用

Cat No : CM17109

Print datasheet

Synonyms

Cardiogenol C|Cardiogenol C HCl|2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐

验证数据展示

  • CAS No.: 1049741-55-0

    Cardiogenol C hydrochloride
    CAS#: 1049741-55-0

产品信息

Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).

CAS号 1049741-55-0
分子式 C13H17ClN4O2
主要靶点 Wnt/beta-catenin
主要通路 干细胞|细胞骨架
分子量 296.75
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Cardiogenol C|Cardiogenol C HCl|2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐

靶点活性

differentiation of ESCs into cardiomyocytes:100 nM (EC50)

体外活性

Cardiogenol C could induce HBPCs to express transcription factors GATA4, Nkx2.5 and Tbx5, which are early specific markers for pre-cardiomyogenic cells[1].

溶解度

H2O:2 mg/mL (6.74 mM),Sonification is recommended.,DMSO:59 mg/mL (198.82 mM)

细胞实验

Used GMEM plus 5 μM Cardiogenol C and 7.5% ESQ-FBS.?The cultures were harvested at different day-intervals after induction for immunohistochemistry, semi-quantitative RT-PCR analysis, western blot analysis and comparative proteomic[1].

参考文献

1.Yau, Winifred WY, Tang, Mei-Kuen, Chen, Elve,et al. Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells[J]. Proteome Science, 9(1):3.
2.Koley M , Mike A K , Heher P , et al. VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes[J]. MedChemComm, 2013, 4(8):1189.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2